Event

This seminar will focus on our recent progresses on developing high-resolution biophotonic imaging technologies, particularly the second-generation optical coherence tomography (OCT) endoscopy and multiphoton endomicroscopy. These technologies have shown significant translational potential for imaging tissue microanatomies in vivo at a resolution approaching or at standard histopathology but without the need for tissue removal, staining or processing. The physics principles, engineering challenges and solutions will be briefly discussed, including the development of advanced lasers, MEMS technology, custom optical fiber, and ultracompact, high-performance imaging optics. Representative applications of these high-resolution technologies will be presented, including cancer detection, airway physiology imaging, preterm birth risk assessment, and intra-operative guidance for neurosurgery. Other potential applications towards basic research such as functional neuroimaging on awake animals will also be discussed.